What were the most devastating "garbage time" injuries?

2 come to mind for me:

• John Randle (1998): On the final defensive snap of the Vikings' 41-21 divisional playoff win against the Cardinals, Randle's main concern was not letting himself get hurt. So what happens? Teammate Derek Alexander falls into his knee, hyperextending it and rendering it ineffective. A healthy Randle probably means the Vikings win the NFCCG rather easily instead of suffering one of the saddest losses in sports history.

• Michael Thomas (2020): With the game largely in hand against the Buccaneers, the Saints were still running plays. Michael Thomas was a blocker on this play that resulted in Latavius Murray falling into his ankle, causing a high-ankle sprain and essentially costing him 2 years of his prime.